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KMID : 0363320030240010044
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Journal of Korean Oriental Internal Medicine
2003 Volume.24 No. 1 p.44 ~ p.54
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Protective effects of Gagaminjakdowha-Tang on liver injury of rats
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Lee Tae-Houn
Kang Jae-Chun
Kim Byung-Woo
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Abstract
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Objectives : This study was done to investigate the protective effects of Gagaminjakdowha-Tang on liver injury of rats induced by CCl_4 and d-galactosamine.
Methods : All animals were divided into 5 groups, those were normal group(untreated), control group(treated with 0.9% Saline solution), sample I group(200mg/kg administrated), sample II group(400mg/kg administrated), Silymarin(200mg/kg administrated) group. Liver injury of rats were induced by CCl_4 and d-galactosamine, and then the serumtransaminase(ALT & AST) alkaline phosphatase(ALP), lactic dehydrogenase(LDH) for enzyme activities, Liver cytosol malondialdehyde(MDA), catalase, superoxide dismutase(SOD), glutathione S-transferase(GST) and glutathione-peroxidase(GPX) for enzyme activities were measured.
Results : The inhibitory effects on the serum ALT activities were noted in both sample I and sample II group. The inhibitory effects on the serum AST activities were noted in only sample II group. The inhibitory effects on the serum ALP activities were noted in both sample I and sample II group. The inhibitory effects on the serum LDH activities were noted in only sample II group. The inhibitory effects on the liver cytosol malondialdehyde were noted in only sample II group. The decresed effects on the liver cytosol catalase activities were inhibited in only sample II group. The decresed effects on the liver cytosol superoxide dismutase activities were inhibited in only sample II group. The decresed effects on the liver cytosol GST activities were inhibited in only sample II group. The decresed effects on the liver cytosol GPX activities were inhibited in only sample II group. The inhibitory effects of the serum ALT activities were noted in both sample I and sample II. The inhibitory effects of the serum AST activities were noted in only sample II group. The inhibitory effects of the serum ALP activities were noted in only sample II group. The inhibitory effects of the serum LDH activities were noted in both sample I and sample II group.
Conclusions : Gagaminjakdowha-Tang has protective effects against liver injury in rats induced by CCl_4 and d-galactosamine.
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KEYWORD
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Gagaminjakdowha-Tang, liver injury, d-galactosamine, CCl_4, Silymarin
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